Evaluation of subclinical alterations in retinal layers and microvascular structures with OCT and OCTA in healthy young short-term smokers.
In: Photodiagnosis & Photodynamic Therapy, Jg. 36 (2021-12-01), S. N.PAG
academicJournal
Zugriff:
• Smoking have ischemic effects on vascular structures, even with short-term exposure. • The increase of macular PD may indicate the ability of superficial vasculature to tolerate hypoxia. • As a result of the vascular effects of smoking, a reduction in choroidal thickness may occur. To detect the changes that can be determined with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in young and short-term smokers. In this cross-sectional, observational, and comparative study, 45 "healthy" smokers and 45 healthy non-smoker control participants were included. Those with a smoking history between 1 year to 5 years and an average of 10–30 cigarettes per day were included in the study. OCT and OCTA measurements were made at least 60 min after smoking and at least 8 h after caffeine-containing beverages in order to end the effect of nicotine on systemic and retinal blood flow in the smoking group. The mean smoking period was 2.2 ± 0.13 years. Mean macular thickness(MMT), retinal nerve fiber layer(RNFL), and choroidal thickness(Cht) were significantly lower in the smoker group, while ganglion cell-inner plexiform layer(GC-IPL) thickness was higher. Vessel density(VD) values were similar between groups, while perfusion density(PD) values were significantly higher in the smoker group. There were significant correlations between MMT and outer VD, outer PD, foveal avascular zone(FAZ) perimeter and circularity index. FAZ area and central VD and PD were inversely correlated. Also, FAZ circularity index and subfoveal, nasal, and temporal ChTs were positively correlated. Despite the short-term smoking, ischemic effects were observed in retinochoroidal and vascular structures. [ABSTRACT FROM AUTHOR]
Copyright of Photodiagnosis & Photodynamic Therapy is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Evaluation of subclinical alterations in retinal layers and microvascular structures with OCT and OCTA in healthy young short-term smokers.
|
---|---|
Autor/in / Beteiligte Person: | Işik, Mehmed Uğur ; Akay, Fahrettin ; Akmaz, Berkay ; Güven, Yusuf Ziya ; Şahin, Ömer Faruk |
Zeitschrift: | Photodiagnosis & Photodynamic Therapy, Jg. 36 (2021-12-01), S. N.PAG |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 1572-1000 (print) |
DOI: | 10.1016/j.pdpdt.2021.102482 |
Sonstiges: |
|