T-cell activation leads to poor activation of HIV-1 clade E LTR.
In: Biotech Week, 2005-03-09, S. 151-152
serialPeriodical
Zugriff:
The article cites a study which reports that T-cell activation leads to poor activation of the HIV- 1 clade E LTR. The enhancer region in the human immunodeficiency virus type 1 5'-long terminal repeat (LTR) is very important for viral transcription. This promoter sequence binds both nuclear factor-kappaB and NFAT, two important modulators of HIV-1 gene expression. In T-cell lines and primary CD4+ T-cells, the results showed that the HIV-1 clade LTR was the weakest LTR regardless of the tested activators, wrote researchers A.M. Lemieux and colleagues. Lemieux and colleagues published their study in the "Journal of Biological Chemistry."
Titel: |
T-cell activation leads to poor activation of HIV-1 clade E LTR.
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Zeitschrift: | Biotech Week, 2005-03-09, S. 151-152 |
Veröffentlichung: | 2005 |
Medientyp: | serialPeriodical |
ISSN: | 1535-2757 (print) |
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