Drug-Coated Balloon Angioplasty for De Novo Lesions on the Left Anterior Descending Artery.
In: Circulation: Cardiovascular Interventions, Jg. 16 (2023-12-01), Heft 12, S. 796-803
academicJournal
Zugriff:
BACKGROUND: Drug-coated balloons (DCB) are an emerging tool for modern percutaneous coronary intervention (PCI), but evidence on their use for de novo lesions on large vessels is limited. METHODS: Consecutive patients undergoing DCB-based PCI on the left anterior descending artery in 2 Italian centers from 2018 to 2022 were retrospectively enrolled and compared with patients who received left anterior descending PCI with contemporary drug-eluting stents (DES). In-stent restenosis was excluded. The DCB group included both patients undergoing DCB-only PCI and those receiving hybrid PCI with DCB and DES combined. The primary end point was target lesion failure at 2 years, defined as the composite of target lesion revascularization, cardiac death, and target vessel myocardial infarction. RESULTS: We included 147 consecutive patients undergoing DCB-based treatment on the left anterior descending artery and compared them to 701 patients who received conventional PCI with DES. In the DCB group, 43 patients (29.2%) were treated with DCB only and 104 (70.8%) with a hybrid approach; DCB length was greater than stent length in 55.1% of cases. Total treated length was higher in the DCB group (65 [40-82] versus 56 [46-66] mm; P=0.002), while longer DESs were implanted (38 [24-62] versus 56 [46--66] mm; P<0.001) and a higher rate of large vessels were treated (76.2% versus 83.5%; P=0.036) in the DES cohort. The cumulative 2-year target lesion failure incidence was not significantly different between the 2 groups (DCB, 4.1% versus DES, 9.8%; hazard ratio, 0.51 [95% CI, 0.20-1.27]; P=0.15). After a 1:1 propensity score matching resulting in 139 matched pairs, the DCB-based treatment was associated with a lower risk for target lesion failure at 2 years compared with DES-only PCI (hazard ratio, 0.2 [95% CI, 0.07-0.58]; P=0.003), mainly driven by less target lesion revascularization. CONCLUSIONS: A DCB-based treatment approach for left anterior descending revascularization allows a significantly reduced stent burden, thereby potentially limiting target lesion failure risk at midterm follow-up. [ABSTRACT FROM AUTHOR]
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Titel: |
Drug-Coated Balloon Angioplasty for De Novo Lesions on the Left Anterior Descending Artery.
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Autor/in / Beteiligte Person: | Gitto, Mauro ; Sticchi, Alessandro ; Chiarito, Mauro ; Novelli, Laura ; Leone, Pier Pasquale ; Mincione, Gianluca ; Oliva, Angelo ; Condello, Francesco ; Rossi, Marco Luciano ; Regazzoli, Damiano ; Gasparini, Gabriele ; Cozzi, Ottavia ; Stefanini, Giulio G. ; Condorelli, Gianluigi ; Reimers, Bernhard ; Mangieri, Antonio ; Colombo, Antonio |
Zeitschrift: | Circulation: Cardiovascular Interventions, Jg. 16 (2023-12-01), Heft 12, S. 796-803 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1941-7640 (print) |
DOI: | 10.1161/CIRCINTERVENTIONS.123.013232 |
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