Incidence of refractory CMV infection with or without antiviral resistance in Spain: A systematic literature review.
In: Transplantation Reviews (0955470X), Jg. 38 (2024), Heft 1, S. N.PAG
academicJournal
Zugriff:
Solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) recipients are susceptible to cytomegalovirus (CMV) infection. The incidence of refractoriness to antivirals, with or without resistance, is unclear. The purpose of this review was to describe the epidemiology of refractory CMV infection in Spain to understand the current unmet needs. PubMed, EMBASE, Cochrane and MEDES were searched systematically for relevant articles. We included randomized controlled trials and observational studies published during the period from January 1990 to June 2021. From 212 screened records, we selected 19 papers including 1973 transplant recipients. Refractory infection ranged from 3 to 10% in studies with SOT recipients. The incidence of CMV resistance ranged from 1% to 36% in these patients. The incidence of CMV refractory infection in HSCT recipients ranged from 11 to 50%, while values for resistant infection ranged from 0% to 21%. The wide range of definitions and values observed does not allow us to establish the true incidence of refractory CMV infection with or without resistances in SOT and HSCT patients in Spain. This review highlights the gap between clinical practice and clinical trials' definitions which needed to be updated to be easier followed in current clinical practice. • Cytomegalovirus infection is one of the most common complications in patients who are recipients of a transplant. • Refractory cytomegalovirus infection remains a challenging clinical concern with significant unmet medical needs. • The incidence of refractory cytomegalovirus infection in Spain is unclear to understand the current unmet needs. [ABSTRACT FROM AUTHOR]
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Titel: |
Incidence of refractory CMV infection with or without antiviral resistance in Spain: A systematic literature review.
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Autor/in / Beteiligte Person: | Aguado, J.M. ; Navarro, D. ; Montoto, C. ; Yébenes, M. ; de Castro-Orós, I. |
Zeitschrift: | Transplantation Reviews (0955470X), Jg. 38 (2024), Heft 1, S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0955-470X (print) |
DOI: | 10.1016/j.trre.2023.100804 |
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