Decoration with electronegative 2D materials based on chemical transition layers on CFR-PEEK implants for promoting osteogenesis.
In: Journal of the Mechanical Behavior of Biomedical Materials, Jg. 152 (2024-04-01), S. N.PAG
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Zugriff:
Due to the unique lamellar structures, physicochemical and biological properties, electronegative two-dimensional (2D) materials have been explored for surface modification of carbon fibers reinforced polyetheretherketone (CFR-PEEK) composite. Deposition of electronegative 2D materials based on a porous surface created by concentrated H 2 SO 4 has been studied to promote osteogenesis of CFR-PEEK. Generally, a porous layer will be pre-built on CFR-PEEK through severe corrosion of concentrated sulfuric acid to help the loading of 2D materials. However, the severe corrosion will greatly reduce surface mechanical strength, especially wear resistance and hardness, which increases the risk of collapse or even peeling of the bioactive coating by external force. Herein, instead of the severe corrosion, a mild corrosion by concentrated HNO 3 was applied to modify the surface of CFR-PEEK to pre-create a dense transition layer for the further surface decoration of electronegative 2D materials (graphene oxide (GO) and black phosphorus (BP), representatively). The results indicated that hardness and wear resistance of the dense transition layer were markedly higher than those of the porous layer. Although GO and BP can be both loaded on these two transition layers, –SO 3 H on the porous transition layer showed moderate cytotoxicity, while –NO 2 on the dense transition layer showed good cytocompatibility. The dense transition layer displayed higher mineralized deposition in vitro and new bone formation rate in vivo than the porous transition layer, moreover, GO and BP coatings improved osteogenesis. This work offers inspirations for the construction of electronegative 2D material coating on CFR-PEEK based on chemical transition layers. • A mild corroded transition layer was pre-created on CFR-PEEK by concentrated HNO 3. • GO and BP successfully modified CFR-PEEK based on chemical transition layer. • Surface modification based on mild corrosion retained high surface strength. • GO and BP coatings promoted osseointegration in vitro and in vivo. [ABSTRACT FROM AUTHOR]
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Titel: |
Decoration with electronegative 2D materials based on chemical transition layers on CFR-PEEK implants for promoting osteogenesis.
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Autor/in / Beteiligte Person: | Qin, Wen ; Xing, Tong ; Ma, Jing ; Tang, Bin ; Chen, Weiyi |
Zeitschrift: | Journal of the Mechanical Behavior of Biomedical Materials, Jg. 152 (2024-04-01), S. N.PAG |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1751-6161 (print) |
DOI: | 10.1016/j.jmbbm.2024.106436 |
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