Synthetic applications of chromium(VI) reagents in combination with chlorotrimethylsilane
In: Canadian Journal of Chemistry, Jg. 64 (1986-02-01), Heft 2, S. 225-231
Online
serialPeriodical
Zugriff:
The synthetic utility of chromium(VI) reagents together with chlorotrimethylsilane, as new oxidizing systems, is described. Pyridinium dichromate (PDC) in combination with chlorotrimethylsilane oxidizes tert-butyldimethylsilyl ethers in good to excellent yields. Trimethylsilyl chlorochromate, a new chromium(VI) reagent, also was found efficient for this oxidative-deprotection method. These reagents were applied to the oxidation of some N-(2-phenyl-2-hydroxyethyl)azetidin-2-ones as well as N-(2-phenyl-2-trialkylsiloxy)azetidin-2-ones into their corresponding carbonyl compounds, key intermediates for N-unsubstituted β-lactams. Oxidation of hydroquinones and protected trialkylsilyl hydroquinones was also described. Protection of hydroquinones by means of the tert-butyldimethylsilyl group was achieved by using the readily available tert-butyldimethylchlorosilane (TBDMCS) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base, which avoids the use of sophisticated and (or) sensitive reagents.
Titel: |
Synthetic applications of chromium(VI) reagents in combination with chlorotrimethylsilane
|
---|---|
Autor/in / Beteiligte Person: | Cossfo, Fernando P. ; Aizpurua, Jesûs M. ; Palomo, Claudio |
Link: | |
Zeitschrift: | Canadian Journal of Chemistry, Jg. 64 (1986-02-01), Heft 2, S. 225-231 |
Veröffentlichung: | 1986 |
Medientyp: | serialPeriodical |
ISSN: | 0008-4042 (print) ; 1480-3291 (print) |
DOI: | 10.1139/v86-039 |
Sonstiges: |
|