Dihydroxyanthranilic Acid as a Precursor of Nicotinic Acid
In: Nature, Jg. 167 (1951-01-20), Heft 4238, S. 115-116
Online
serialPeriodical
Zugriff:
A MIXTURE of 400 mgm. of o-aminoveratric acid (prepared by the method of Pschorr and Sumuleanu1), 100 mgm. of red phosphorus and 8 ml. of hydriodic acid (sp. gr. 1.7) was heated in a sealed tube at 100° for eight hours and then at 105° for two hours. The hydriodic acid salt of 2-amino-3,4-dihydroxybenzoic acid crystallized on cooling. After filtration, this product was recrystallized from a small amount of hydriodic acid containing water and obtained as macroscopic prismatic needles (m.p. 220°; found: N, 4.29; C7H8O4NI requires N, 4.71 per cent). The hydriodide of dioxyanthranilic acid was easily dissociated by washing with a larger amount of water, and the free acid was recrystallized from alcohol (m.p. 174°; found: N, 8.05; C7H7O4N requires N, 8.29 per cent).
| Titel: |
Dihydroxyanthranilic Acid as a Precursor of Nicotinic Acid
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| Autor/in / Beteiligte Person: | MAKINO, KATASHI ; ITOH, FUMIO ; NISHI, KEIKO |
| Link: | |
| Zeitschrift: | Nature, Jg. 167 (1951-01-20), Heft 4238, S. 115-116 |
| Veröffentlichung: | 1951 |
| Medientyp: | serialPeriodical |
| ISSN: | 0028-0836 (print) ; 1476-4687 (print) |
| DOI: | 10.1038/167115a0 |
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