Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome
In: Nature, Jg. 267 (1977-05-12), Heft 5607, S. 165-167
Online
serialPeriodical
Zugriff:
THE best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1–4; 14–16). Human and animal interferons have various immunosuppressive effects5–10, among them the inhibition in vitro of DNA synthesis in activated lymphocytes11. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.
Titel: |
Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome
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Autor/in / Beteiligte Person: | CUPPLES, CLAIRE G. ; TAN, Y. H. |
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Zeitschrift: | Nature, Jg. 267 (1977-05-12), Heft 5607, S. 165-167 |
Veröffentlichung: | 1977 |
Medientyp: | serialPeriodical |
ISSN: | 0028-0836 (print) ; 1476-4687 (print) |
DOI: | 10.1038/267165a0 |
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