Lectin-like Oxidized Low-Density Lipoprotein (LDL) Receptor (LOX-1): A Chameleon Receptor for Oxidized LDL
In: Biochemistry, Jg. 55 (2016-08-16), Heft 32, S. 4437-4444
serialPeriodical
Zugriff:
LOX-1, one of the main receptors for oxLDL, is found mainly on the surface of endothelial cells. It is a multifacet 52 kDa type II transmembrane protein that structurally belongs to the C-type lectin family. It exists with short intracellular N-terminal and long extracellular C-terminal hydrophilic domains separated by a hydrophobic domain of 26 amino acids. LOX-1 acts like a bifunctional receptor either showing pro-atherogenicity by activating the NFκB-mediated down signaling cascade for gene activation of pro-inflammatory molecules or playing an atheroprotective agent by receptor-mediated uptake of oxLDL in the presence of an anti-inflammatory molecule like IL-10. Mildly, moderately, and highly oxidized LDL show their characteristic features upon LOX-1 activation and its ligand binding indenture. The polymorphic LOX-1 genes are intensively associated with increased susceptibility to myocardial diseases. The splicing variant LOX IN dimerizes with the native form of LOX-1 and protects cells from damage by oxidized LDL. In the developing field of regenerating medicine, LOX-1 is a potential target for therapeutic intervention.
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Lectin-like Oxidized Low-Density Lipoprotein (LDL) Receptor (LOX-1): A Chameleon Receptor for Oxidized LDL
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Autor/in / Beteiligte Person: | Zeya, Bushra ; Arjuman, Albina ; Chandra, Nimai Chand |
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Zeitschrift: | Biochemistry, Jg. 55 (2016-08-16), Heft 32, S. 4437-4444 |
Veröffentlichung: | 2016 |
Medientyp: | serialPeriodical |
ISSN: | 0006-2960 (print) ; 1520-4995 (print) |
DOI: | 10.1021/acs.biochem.6b00469 |
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