Inhibition of lipoprotein lipase by the receptor‐binding domain of apolipoprotein E
In: FEBS Letters, Jg. 251 (1989-07-17), Heft 1-2, S. 250-252
Online
serialPeriodical
Zugriff:
A synthetic peptide (residues 139–153) corresponding to the receptor‐binding domain of apolipoprotein E (ApoE) was tested for lipoprotein lipase (LPL) inhibitory properties. In systems using both natural and synthetic substrates, inhibition of LPL was observed. Using the synthetic substrate, 50% inhibition was observed at 50 μM while high concentrations completely inhibited LPL activity. These studies suggest an additional functional role for the receptor‐binding domain of ApoE — modulation of LPL activity.
Titel: |
Inhibition of lipoprotein lipase by the receptor‐binding domain of apolipoprotein E
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Autor/in / Beteiligte Person: | McConathy, Walter.J. ; Wang, Chi-Sun |
Link: | |
Zeitschrift: | FEBS Letters, Jg. 251 (1989-07-17), Heft 1-2, S. 250-252 |
Veröffentlichung: | 1989 |
Medientyp: | serialPeriodical |
ISSN: | 0014-5793 (print) |
DOI: | 10.1016/0014-5793(89)81464-4 |
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