TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus
In: Antimicrobial Agents and Chemotherapy, Jg. 42 (1998-02-01), Heft 2, S. 383-388
Online
serialPeriodical
Zugriff:
ABSTRACTWe have evaluated the clinical potential of TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate (TXU-PAP) as a new biotherapeutic anti-human immunodeficiency virus (anti-HIV) agent by evaluating its anti-HIV type 1 (anti-HIV-1) activity in vitro, as well as in a surrogate human peripheral blood lymphocyte-severe combined immunodeficient (Hu-PBL-SCID) mouse model of human AIDS. The present report documents in a side-by-side comparison the superior in vitro anti-HIV-1 activity of TXU-PAP compared to the activities of zidovudine, 2′,3′-didehydro-2′,3′-dideoxythymidine, unconjugated PAP, and B53-PAP, an anti-CD4-PAP immunoconjugate. Notably, TXU-PAP elicited potent anti-HIV activity in the Hu-PBL-SCID mouse model of human AIDS without any side effects and at doses that were very well tolerated by cynomolgus monkeys. Furthermore, plasma samples from TXU-PAP-treated cynomolgus monkeys showed potent anti-HIV-1 activity in vitro.
Titel: |
TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus
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Autor/in / Beteiligte Person: | Uckun, Fatih M. ; Chelstrom, Lisa M. ; Tuel-Ahlgren, Lisa ; Dibirdik, Ilker ; Irvin, James D. ; Langlie, Mridula-Chandan ; Myers, Dorothea E. |
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Zeitschrift: | Antimicrobial Agents and Chemotherapy, Jg. 42 (1998-02-01), Heft 2, S. 383-388 |
Veröffentlichung: | 1998 |
Medientyp: | serialPeriodical |
ISSN: | 0066-4804 (print) ; 1098-6596 (print) |
DOI: | 10.1128/AAC.42.2.383 |
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