Experimental tumoricidal effects of monoclonal antibody against solid breast tumors.
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 80 (1983-12-01), Heft 23, S. 7328-7332
Online
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Zugriff:
Two distinct monoclonal antibodies (mAbs) were effective in the therapy of breast carcinomas of human origin established and growing in nude mice. Passive administration of either of the antibodies produced very rapid (less than 1 week) and significant reduction of in vivo tumor volume. Each of the mAbs showed in vivo targeting of the tumors. Histological analysis of mAb-treated tumors revealed extensive cellular necrosis. Each of the antibodies in vitro was effective in complement-mediated cytolysis at a concentration less than 1 ng/ml. The tumoricidal responses show that this is a useful model for passive human immunotherapy using mAbs.
| Titel: |
Experimental tumoricidal effects of monoclonal antibody against solid breast tumors.
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| Autor/in / Beteiligte Person: | Capone, P M ; Papsidero, L D ; Croghan, G A ; Chu, T M |
| Link: | |
| Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 80 (1983-12-01), Heft 23, S. 7328-7332 |
| Veröffentlichung: | 1983 |
| Medientyp: | serialPeriodical |
| ISSN: | 0027-8424 (print) ; 1091-6490 (print) |
| DOI: | 10.1073/pnas.80.23.7328 |
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