Elevated IL-18 Predicts Poor Prognosis in Critically ill COVID-19 Patients at a Brazilian Hospital in 2020–21
In: Future Microbiology, Jg. 17 (2022-11-01), Heft 16, S. 1287-1294
serialPeriodical
Zugriff:
Background:A dysregulated inflammatory response contributes to decline in patients with COVID-19. This cross-sectional study evaluated biomarkers of unvaccinated patients admitted to the intensive care unit of a hospital in Fortaleza, Brazil. Methods:Twenty cytokines were quantified upon hospital admission; clinical and laboratory data were analyzed, as well as sociodemographic data, to search for an association with clinical outcomes, including fatal (n = 40) or recovered cases (n = 38). Results:Fatal cases exhibited significantly higher levels of IL-18 (p = 0.009); deceased patients were older (p = 0.0001), had a lower number of platelets (p = 0.0063) and higher neutrophil–lymphocyte ratio (p = 0.0230) than those who recovered. Conclusion:These findings indicate that IL-18 is a possible marker to predict poor prognosis in critically ill patients with COVID-19.
| Titel: |
Elevated IL-18 Predicts Poor Prognosis in Critically ill COVID-19 Patients at a Brazilian Hospital in 2020–21
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| Autor/in / Beteiligte Person: | Coutinho, Lucyana LC ; Oliveira, Caroline N ; Albuquerque, Polianna LMM ; Mota, Sandra MB ; Meneses, Gdayllon C ; Martins, Alice MC ; Junior, Geraldo BS ; Clementino, Marco AF ; Gondim, Rafhaella NDG ; Havt, Alexandre ; Cavalcanti, Luciano PG ; Yaochite, Juliana NU |
| Zeitschrift: | Future Microbiology, Jg. 17 (2022-11-01), Heft 16, S. 1287-1294 |
| Veröffentlichung: | 2022 |
| Medientyp: | serialPeriodical |
| ISSN: | 1746-0913 (print) ; 1746-0921 (print) |
| DOI: | 10.2217/fmb-2022-0057 |
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