Calcofluor white-cholesteryl hydrogen succinate conjugate mediated liposomes for enhanced targeted delivery of voriconazole into Candida albicansElectronic supplementary information (ESI) available: Stability assay of CFW-CHSc-VRC-liposomes and VRC-liposomes. 13C NMR spectrum of CFW. See DOI: https://doi.org/10.1039/d2bm01263d
In: Biomaterials Science, Jg. 11 (2022), Heft 1, S. 307-321
serialPeriodical
Zugriff:
Fungal infections gradually lead to a high mortality rate due to difficulties in diagnosis, the limited number of antifungal drugs available, and the appearance of resistant isolates. Here, we developed a calcofluor white-cholesteryl hydrogen succinate conjugate (CFW–CHSc) as a novel nanomaterial that specifically binds to chitin chains in the cell wall. We showed that fluorescent-dye loaded CFW–CHSc-liposomes entered the cytoplasm of Candida albicanscells with increased efficacy. Voriconazole-loaded CFW–CHSc-liposomes displayed an increased antifungal activity against C. albicansyeast cells in an in vitroassay. Animal infection models and animal imaging analysis showed that fluorescent-dye loaded CFW–CHSc-liposomes maintained prolonged residence in rodent tissues. In mouse liver and kidney tissue, voriconazole-loaded CFW–CHSc-liposomes showed significantly enhanced antifungal activity when administered intravenously. Taken together, our studies confirm that CFW–CHSc increases the drug delivery efficacy of nanoparticles in vitroby interacting with chitin chains in the C. albicanscell wall. The fungi-targeting nanoparticles improve the drug delivery efficacy in vivoby enriching the nanoparticles at the site of fungal infection viathe blood circulation system. Fungi-targeting nanomaterials have a promising future in the treatment of nosomycosis.
Titel: |
Calcofluor white-cholesteryl hydrogen succinate conjugate mediated liposomes for enhanced targeted delivery of voriconazole into Candida albicansElectronic supplementary information (ESI) available: Stability assay of CFW-CHSc-VRC-liposomes and VRC-liposomes. 13C NMR spectrum of CFW. See DOI: https://doi.org/10.1039/d2bm01263d
|
---|---|
Autor/in / Beteiligte Person: | Liu, Wei ; Li, Mengshun ; Tian, Baocheng ; Yang, Xuesong ; Du, Wei ; Wang, Xiuwen ; Zhou, Huihui ; Ding, Chen ; Sai, Sixiang |
Zeitschrift: | Biomaterials Science, Jg. 11 (2022), Heft 1, S. 307-321 |
Veröffentlichung: | 2022 |
Medientyp: | serialPeriodical |
ISSN: | 2047-4830 (print) ; 2047-4849 (print) |
DOI: | 10.1039/d2bm01263d |
Sonstiges: |
|