Three-Component Domino Acylation/Trifluoromethylation of Bicyclic Amidines
In: Organic Letters, 2023, Heft Preprints
serialPeriodical
Zugriff:
We herein describe a three-component reaction involving bicyclic amidines such as DBN/DBU, acyl fluorides, and TMSCF3for access to a novel class of N-acyl trifluoromethylated bicyclic aminals. Under mild and operationally simple conditions, bicyclic amidines can undergo difunctionalization (acylation/trifluoromethylation) using readily available reagents. Further Lewis acid-promoted nucleophilic ring-opening can lead to diverse products with quaternary carbon centers containing CF3. The corresponding pentafluoroethylation is also achieved by using TMSC2F5.
Titel: |
Three-Component Domino Acylation/Trifluoromethylation of Bicyclic Amidines
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Autor/in / Beteiligte Person: | Luo, Ziwei ; Chen, Jiahua ; Li, Mengwan ; Tsui, Gavin Chit |
Link: | |
Zeitschrift: | Organic Letters, 2023, Heft Preprints |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1523-7060 (print) ; 1523-7052 (print) |
DOI: | 10.1021/acs.orglett.3c02050 |
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