Cytotoxic Stress Transiently Increases the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production
In: Blood, Jg. 142 (2023-11-28), Heft 1, Number 1 Supplement 1, S. 34-34
serialPeriodical
Zugriff:
While hematopoietic stem cells (HSCs) and megakaryocyte (Mk)/platelet lineages exhibit substantial phenotypic and transcriptional overlap, direct Mk production from HSCs is still under investigation. In particular, the hypothesis that specific HSC clones might facilitate rapid megakaryopoiesis and their physiological roles are yet to be elucidated. Previous clonal studies using either single cell transplantations (Yamamoto, Cell 2013; Carrelha, Nature 2018) or barcoding assays (Pei, Cell Stem Cell 2020; Rodriguez-Fraticelli, Nature 2020) have identified subsets of HSCs with Mk-biased output, designated as Mk-biased HSCs or platelet-biased HSCs (P-HSCs), in contrast to multi-lineage HSCs (MUL-HSCs) with balanced output. Moreover, P-HSCs exhibit up-regulated platelet-lineage gene expression and chromatin accessibility, and they generate platelets at a faster rate than MUL-HSCs, pointing towards a direct platelet formation pathway (Rodriguez-Fraticelli, Nature 2020; Meng, 2023 Nat Cell Biol). Notably, under inflammatory stress, direct Mk progenitor (MkP) production and Mk formation from HSCs have been shown to accelerate (Haas, Cell Stem Cell, 2015; Morcos, Nat Commun 2022), suggesting that P-HSCs could drive rapid platelet production during hematopoietic emergencies.
Titel: |
Cytotoxic Stress Transiently Increases the Contribution of Platelet-Biased Hematopoietic Stem Cells to Platelet Production
|
---|---|
Autor/in / Beteiligte Person: | Meng, Yiran ; Ren, Xiying ; Li, Rong ; Zhang, Bowen ; Nerlov, Claus |
Zeitschrift: | Blood, Jg. 142 (2023-11-28), Heft 1, Number 1 Supplement 1, S. 34-34 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 0006-4971 (print) ; 1528-0020 (print) |
DOI: | 10.1182/blood-2023-184661 |
Sonstiges: |
|