Evaluation of biological effectiveness of 65 MeV therapeutic proton beams using the GATE platform
In: Third Geant4 International User Conference Third Geant4 International User Conference, Oct 2018, Bordeaux, France; (2018-10-29)
Online
unknown
Zugriff:
International audience; Introduction: In order to optimize hadrontherapy treatments, it is needed to consider the biological effect on irradiated tumor cells. The biological dose can be evaluated through biophysical models, such as the Microdosimetric Kinetic Model (MKM)[1-5]. This model is implemented to take into account a corrected lineal energy spectrum obtained from Monte Carlo simulations and the model parameters of irradiated cells obtained from experiments. The purpose of this study is to validate the implementation of the MKM model into GATE through the simulation of the 65 MeV therapeutic proton beam (MediCyc) of Antoine Lacassagne centre for the estimation of the relative biological effectiveness (RBE).
| Titel: |
Evaluation of biological effectiveness of 65 MeV therapeutic proton beams using the GATE platform
|
|---|---|
| Autor/in / Beteiligte Person: | Ali, Yasmine ; Degoul, Françoise ; Debiton, Eric ; Hérault, Joël ; Vidal, Marie ; Maigne, Lydia ; Laboratoire de Physique de Clermont (LPC) ; Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS) ; Imagerie Moléculaire et Stratégies Théranostiques (IMoST) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) ; Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL) ; UNICANCER-Université Côte d'Azur (UCA) ; Rayet, Béatrice ; Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3) ; Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Link: | |
| Quelle: | Third Geant4 International User Conference Third Geant4 International User Conference, Oct 2018, Bordeaux, France; (2018-10-29) |
| Veröffentlichung: | HAL CCSD, 2018 |
| Medientyp: | unknown |
| Schlagwort: |
|
| Sonstiges: |
|