UropathogenicEscherichia coliST131 in urinary tract infections in children
In: Korean Journal of Pediatrics, Jg. 60 (2017), S. 221-221
Online
unknown
Zugriff:
PURPOSE Escherichia coli sequence type (ST) 131, a multidrug-resistant clone causing extraintestinal infections, has rapidly become prevalent worldwide. However, the epidemiological and clinical features of pediatric infections are poorly understood. We aimed to explore the characteristics of ST131 Escherichia coli isolated from Korean children with urinary tract infections. METHODS We examined 114 uropathogenic E. coli (UPEC) isolates from children hospitalized at Chung-Ang University Hospital between 2011 and 2014. Bacterial strains were classified into STs by partial sequencing of seven housekeeping genes (adk, fumC, gyrB, icd, mdh, purA, and recA). Clinical characteristics and antimicrobial susceptibility were compared between ST131 and non-ST131 UPEC isolates. RESULTS Sixteen UPEC isolates (14.0%) were extended-spectrum β-lactamase (ESBL)-producers; 50.0% of ESBL-producers were ST131 isolates. Of all the isolates tested, 13.2% (15 of 114) were classified as ST131. There were no statistically significant associations between ST131 and age, sex, or clinical characteristics, including fever, white blood cell counts in urine and serum, C-reactive protein, radiologic abnormalities, and clinical outcome. However, ST131 isolates showed significantly lower rates of susceptibility to cefazolin (26.7%), cefotaxime (40.0%), cefepime (40.0%), and ciprofloxacin (53.3%) than non-ST131 isolates (65.7%, 91.9%, 92.9%, and 87.9%, respectively; P
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UropathogenicEscherichia coliST131 in urinary tract infections in children
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Autor/in / Beteiligte Person: | Lee, Mi-Kyung ; In Seok Lim ; Ki Wook Yun ; Kim, Wonyong |
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Zeitschrift: | Korean Journal of Pediatrics, Jg. 60 (2017), S. 221-221 |
Veröffentlichung: | Korean Pediatric Society, 2017 |
Medientyp: | unknown |
ISSN: | 2092-7258 (print) ; 1738-1061 (print) |
DOI: | 10.3345/kjp.2017.60.7.221 |
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