Effects of immunosuppressant FK-506 on tooth movement
In: Orthodontics & Craniofacial Research, Jg. 13 (2010-07-06), S. 153-161
Online
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Zugriff:
To cite this article: Santos RL, de Farias MLF, de Mendonca LMC, Goncalves RT, Martins MA, de Souza MMG: Effects of immunosuppressant FK-506 on tooth movement Orthod Craniofac Res 2010;13:153–161 Structured Abstract Authors – Santos RL, de Farias MLF, de Mendonca LMC, Goncalves RT, Martins MA, de Souza MMG Objective – To test the hypothesis that immunosuppressant tacrolimus treatment can interfere with bone turnover and rate of tooth movement. Material and Methods – One-hundred twenty Wistar male rats were divided into four groups: Group 1 (rats subjected to orthodontic movement plus treatment with saline solution vehicle), Group 2 (rats subjected to orthodontic movement plus treatment with FK506), Group 3 (rats treated with FK506 only), and Group 4 (rats treated with saline solution vehicle). The maxillary incisors were laterally moved with a reciprocal load of 35 cN. The dosage of FK506 was 2 mg/kg/day. Howship’s lacunae, osteoclasts, and macrophages were counted. Results – Tooth movement was found to be greater in Group 1 than in Group 2 for all time periods (on days 3, 7, and 14), although a significant difference was observed only on days 7 and 14 (p
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Effects of immunosuppressant FK-506 on tooth movement
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Autor/in / Beteiligte Person: | Martins, MA ; Farias, Mlf ; Mmg De Souza ; Santos, RL ; Gonçalves, RT ; Mendonça, Lmc |
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Zeitschrift: | Orthodontics & Craniofacial Research, Jg. 13 (2010-07-06), S. 153-161 |
Veröffentlichung: | Wiley, 2010 |
Medientyp: | unknown |
ISSN: | 1601-6343 (print) ; 1601-6335 (print) |
DOI: | 10.1111/j.1601-6343.2010.01489.x |
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