Synthesis, DNA-binding properties and cytotoxicity evaluation of two copper(II) complexes based on curcumin
In: Transition Metal Chemistry, Jg. 41 (2016-02-18), S. 331-337
Online
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Zugriff:
Two Cu(II) complexes based on curcumin, namely CuL 2 1 [HL1 = 1,7-bis[4-(2-oxymethylenepyridine)-3-methoxyl]phenyl-1,6-heptadiene-3,5-diketone] and CuL 2 2 [HL2 = 1,7-bis[4-(3-oxymethylene-2-chlorothiophene)-3-methoxyl] phenyl-1,6-heptadiene-3,5-diketone], have been synthesized and characterized by physico-chemical and spectroscopic methods. The interactions of calf thymus DNA (CT-DNA) with both complexes have been investigated by UV–Vis absorption, fluorescence and viscosity titration methods. Both complexes are found to interact with CT-DNA by intercalative binding modes. Evaluation of the cytotoxicities of the complexes against three human tumor cells showed that they have potent cytotoxicities against all three cell lines.
Titel: |
Synthesis, DNA-binding properties and cytotoxicity evaluation of two copper(II) complexes based on curcumin
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Autor/in / Beteiligte Person: | Wang, Jiafeng ; Wang, Chengming ; Si, Guifu ; Xue, Xuan ; Zhou, Shuangsheng |
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Zeitschrift: | Transition Metal Chemistry, Jg. 41 (2016-02-18), S. 331-337 |
Veröffentlichung: | Springer Science and Business Media LLC, 2016 |
Medientyp: | unknown |
ISSN: | 1572-901X (print) ; 0340-4285 (print) |
DOI: | 10.1007/s11243-016-0027-6 |
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