Maternal Vaping during Pregnancy E-cigs Leads to Obesity in Offspring
In: Physiology, Jg. 38 (2023-05-01)
Online
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Zugriff:
Electronic cigarettes (E-cigs) have been strategically marketed as a safer alternative to smoking even during pregnancy. Previous literature suggests that direct exposure to E-cigs disrupts insulin sensitivity and mitochondrial function. Yet, there are few studies looking into maternal E-cig exposure and the metabolic function of offspring, especially separating out the role of nicotine. We hypothesize that maternal vaping would induce vascular and metabolic disruption in offspring leading to obesity in adulthood. Female rats (N=25) were time-mated, and randomly assigned to the following exposure groups, ambient air (control, N=5), Ecig with no nicotine at either 5 (w)att or 30w (Ecig0-5w, n=5; Ecig0-30w, n=5) or Ecig with 50mg of nicotine (Ecig50-5w, n=5; Ecig50-30w, n=5). Exposure was 60 puffs/day (1.5hr/day, 5 days/week) beginning on gestational day 2-4 using whole-body chambers. E-liquid composition 50:50 vegetable glycerin, propylene glycol with no flavoring. Postnatal day ((PD)21) offspring were weighed and body composition was measured using an EchoMRI. Total fat, lean, and water content were measured. As the animal's aged body mass was recorded at 1-, 3-, 6-, and 12-months. Body weight at PD21 was significantly decreased in female (-16%±4%) and male (-18%±4%) offspring with all Ecig0 groups (independent of wattage) (p AHA Collaborative Science Award This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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Maternal Vaping during Pregnancy E-cigs Leads to Obesity in Offspring
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Autor/in / Beteiligte Person: | Mills, Amber ; Nassabeh, Sydney ; Frazier, James ; Robinson, Madison ; Legg, Preston ; Shamma, Allison ; Hurley, Audra ; Chantler, Paul ; Dakhallah, Duaa ; Boyd, Jonathan ; I. Mark Olfert |
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Zeitschrift: | Physiology, Jg. 38 (2023-05-01) |
Veröffentlichung: | American Physiological Society, 2023 |
Medientyp: | unknown |
ISSN: | 1548-9221 (print) ; 1548-9213 (print) |
DOI: | 10.1152/physiol.2023.38.s1.5729326 |
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