S-lOO-Positive T-Cell Lymphoproliferative Disorder:A Case Report and Review of the Literature
In: American Journal of Clinical Pathology, Jg. 102 (1994-10-01), S. 478-482
Online
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Zugriff:
The authors describe a patient with a S-100-positive T-cell lymphoproliferative disorder, characterized by clinically aggressive behavior, with leukemic dissemination and death within 1 year of the onset of symptoms. The neoplastic cells had abundant amphophilic cytoplasm, suggestive of plasmacytoid differentiation, but demonstrated a mature T-cell immunophenotype characteristic of the suppressor-cytotoxic subset. In addition, the cells expressed the S-100 protein within the cytoplasm. Genotypic studies were performed by Southern blot analysis, which demonstrated β-chain T-cell receptor gene rearrangement, further confirming the T-cell nature of this disorder. This case had futures very similar to those of the seven cases previously reported
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S-lOO-Positive T-Cell Lymphoproliferative Disorder:A Case Report and Review of the Literature
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Autor/in / Beteiligte Person: | Zarate-Osorno, A. ; Jaffe, Elaine S. ; Andrade, Rafael ; Raffeld, Mark ; Berman, Errol ; M. Mercedes Ferguson |
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Zeitschrift: | American Journal of Clinical Pathology, Jg. 102 (1994-10-01), S. 478-482 |
Veröffentlichung: | Oxford University Press (OUP), 1994 |
Medientyp: | unknown |
ISSN: | 1943-7722 (print) ; 0002-9173 (print) |
DOI: | 10.1093/ajcp/102.4.478 |
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