Evaluation of antioxidant effect of Nerium indicum in anxious rats
In: Indian Journal of Pharmacology, Jg. 48 (2016), S. 430-430
Online
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Zugriff:
Aim: The aim of this study was to analyze the ethyl acetate extract of Nerium indicum (NIE) flower for its antioxidant effect in anxious Sprague–Dawley rats. Materials and Methods: Animals were divided into six groups (n = 6) and treated with 200 mg/kg and 400 mg/kg p.o. of NIE for 21 days to assess its preventive and curative effects. Anxiety was induced by isolating animals socially for 21 days. Elevated plus maze (EPM) and light and dark model were used for measuring anxiety in animals. Oxidative stress parameters such as lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in blood and brain tissue homogenate were monitored after 21 days of social isolation in animals. Results: Rats were treated with NIE 200 mg/kg and 400 mg/kg p.o. Both the treatments showed a significant (P Conclusion: The present study suggests the role of NIE in the treatment of anxiety, possibly by modulating the oxidative stress.
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Evaluation of antioxidant effect of Nerium indicum in anxious rats
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Autor/in / Beteiligte Person: | Amol G Jawarkar ; Abhijit V Shrirao ; Alok Shiomurthi Tripathi ; Mohale, D. S. ; Chandewar, Anil V. |
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Zeitschrift: | Indian Journal of Pharmacology, Jg. 48 (2016), S. 430-430 |
Veröffentlichung: | Medknow, 2016 |
Medientyp: | unknown |
ISSN: | 0253-7613 (print) |
DOI: | 10.4103/0253-7613.186201 |
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