DBU-mediated [4 + 2] annulations of donor–acceptor cyclopropanes with 3-aryl-2-cyanoacrylates for the synthesis of fully substituted anilines
In: RSC Advances, Jg. 7 (2017), S. 38342-38349
Online
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Zugriff:
A facile synthesis of fully substituted anilines by the DBU-mediated [4 + 2] annulation of donor–acceptor 1,1-dicyano-cyclopropanes with 3-aryl-2-cyanoacrylate has been developed. This reaction involves a highly efficient multiple domino sequence consisting of ring opening of donor–acceptor cyclopropanes, regioselective intermolecular Michael addition, intramolecular nucleophilic addition and aromatization as key unit steps. This transformation provides a straightforward synthetic protocol for constructing fully substituted aniline derivatives. The structure of two typical products was confirmed by X-ray crystallography.
Titel: |
DBU-mediated [4 + 2] annulations of donor–acceptor cyclopropanes with 3-aryl-2-cyanoacrylates for the synthesis of fully substituted anilines
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Autor/in / Beteiligte Person: | Wang, Cunde ; Qian, Siran ; Su, Zhenjie ; Liu, Jiaming |
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Zeitschrift: | RSC Advances, Jg. 7 (2017), S. 38342-38349 |
Veröffentlichung: | Royal Society of Chemistry (RSC), 2017 |
Medientyp: | unknown |
ISSN: | 2046-2069 (print) |
DOI: | 10.1039/c7ra07230a |
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