Cobalt(<scp>ii</scp>) 8-hydroxyquinoline complexes: structure, cytotoxicity and action mechanism
In: MedChemComm, Jg. 7 (2016), S. 806-812
Online
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Zugriff:
Three cobalt(II) complexes, [Co(NOQ)2(C5H5N)2]C2H5OH (1), [Co(BrQ)2(C5H5N)2] (2) and [Co(NQ)2(C5H5N)2] (3) (NOQ = 5-nitro-8-hydroxyquinoline, BrQ = 5-bromo-8-hydroxyquinoline, NHQ = 2-amino-8-hydroxyquinoline), were synthesized and characterized. Their in vitro cytotoxicity against T-24, BEL-7404, HepG2, HeLa, MGC-803, SKOV-3, HL-7702 and WI-38 cell lines was evaluated. Complexes 1–3 exhibited the highest proliferation inhibition activity against the T-24 tumor cell line with IC50 values in the range between 7.00 and 16.70 μM. They also displayed selectivity towards T-24 tumor cell lines compared to the normal liver cell line HL-7702 and human fetal lung fibroblast WI-38 cell line. The action mechanism of complex 1 was investigated. It caused apoptotic death of the T-24 cells via G1 cell cycle arrest. Further investigation revealed that complex 1 induced overproduction of reactive oxygen species, which led to mitochondrion-mediated apoptosis. DNA binding studies suggested that intercalation might be the most probable binding mode of the Co(II) complexes with ct-DNA.
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Cobalt(<scp>ii</scp>) 8-hydroxyquinoline complexes: structure, cytotoxicity and action mechanism
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Autor/in / Beteiligte Person: | Liu, You-Nian ; Qin, Qi-Pin ; Meng, Ting ; Liu, Yan-Cheng ; Huang, Ke-Bin ; Liang, Hong ; Zhang, Hai-Rong ; Chen, Zhen-Feng ; Zou, Bi-Qun |
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Zeitschrift: | MedChemComm, Jg. 7 (2016), S. 806-812 |
Veröffentlichung: | Royal Society of Chemistry (RSC), 2016 |
Medientyp: | unknown |
ISSN: | 2040-2511 (print) ; 2040-2503 (print) |
DOI: | 10.1039/c6md00073h |
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