DBU-Catalyzed Inter- and Intramolecular Double Michael Addition of Donor–Acceptor Chromone-Pyrazolone/Benzofuranone Synthons: Access to Spiro-Pyrazolone/Benzofuranone-Hexahydroxanthone Hybrids
In: Synthesis, Jg. 52 (2019-09-13), S. 85-97
Online
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Zugriff:
A DBU-catalyzed inter- and intramolecular double Michael addition of donor–acceptor chromone-pyrazolone/benzofuranone synthons and 3-methyl-4-nitro-5-alkenylisoxazoles has been established, which constructed structurally diverse spiro-pyrazolone/benzofuranone-hexahydroxanthone hybrids bearing five consecutive stereocenters in good yields (up to 91%) with high diastereoselectivities (up to >20:1 dr). Moreover, this strategy further expanded the synthetic potential of bifunctional donor–acceptor chromones, and demonstrated great potential for applications in medicinal chemistry.
Titel: |
DBU-Catalyzed Inter- and Intramolecular Double Michael Addition of Donor–Acceptor Chromone-Pyrazolone/Benzofuranone Synthons: Access to Spiro-Pyrazolone/Benzofuranone-Hexahydroxanthone Hybrids
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Autor/in / Beteiligte Person: | Shunqin, Chang ; Qi Di Wei ; Yang, Wu-De ; Tian, Min-Yi ; Zhou, Ying ; Yao, Yi-Ming ; Liu, Xiong-Li |
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Zeitschrift: | Synthesis, Jg. 52 (2019-09-13), S. 85-97 |
Veröffentlichung: | Georg Thieme Verlag KG, 2019 |
Medientyp: | unknown |
ISSN: | 1437-210X (print) ; 0039-7881 (print) |
DOI: | 10.1055/s-0037-1610728 |
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