Chronic pain and delinquency partially explain the effect of the DRD4 gene polymorphism on adult substance use
In: The American Journal of Drug and Alcohol Abuse, Jg. 48 (2021-10-28), S. 235-244
Online
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Zugriff:
Background: The dopamine receptor D4 [DRD4] has been reported to be associated with substance use. Yet, the roles that health conditions and behaviors may play in such association are understudied.Objective: This longitudinal study investigated the potential mediation effects of chronic pain and delinquency in adolescence on the association between the DRD4 2-repeat allele and substance use in adulthood. Sex, witnessing violence, and experiencing violence were also examined as potential moderators for the mediation pathways.Methods: We used the restricted and candidate gene data from the National Longitudinal Study of Adolescent to Adult Health (Waves I-IV) to conduct secondary analysis (N = 8,671; 47% male). A two-step approach was adopted to examine the mediation effects regarding four substance use outcomes in adulthood: number of lifetime alcohol use disorder symptoms, lifetime regular smoker status, past-month smoking, and lifetime "pain killer" misuse. The moderation effects were investigated using stratification and permutation.Results: The DRD4 2-repeat allele was associated with all adulthood substance use outcomes through adolescent chronic pain and delinquency (AORs/IRR range 1.08-3.78; all ps
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Chronic pain and delinquency partially explain the effect of the DRD4 gene polymorphism on adult substance use
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Autor/in / Beteiligte Person: | Lin, Hsien-Chang ; Trucco, Elisa M. ; Wang, Zhi ; Buu, Anne ; James J Yang |
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Zeitschrift: | The American Journal of Drug and Alcohol Abuse, Jg. 48 (2021-10-28), S. 235-244 |
Veröffentlichung: | Informa UK Limited, 2021 |
Medientyp: | unknown |
ISSN: | 1097-9891 (print) ; 0095-2990 (print) |
DOI: | 10.1080/00952990.2021.1977311 |
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