New phosphitylating reagent in the nucleotide chemistry containing two 4-nitrophenoxy leaving groups. Remarkably fast and clean phosphitylations activated by DBU leading to thio- and seleno-oligonucleotides
In: Tetrahedron Letters, Jg. 34 (1993-10-01), S. 6451-6454
Online
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Zugriff:
A new synthetic approach to modified oligonucleotides based on N,N′-diisopropyl-di-(4-nitrophenyl)phosphoroamidite 1 is described. The procedure involves displacement of either 4-nitrophenoxy or diisopropylamino ligands. The former proceeds very fast in the presence of DBU, the latter requires activation by tetrazole. This method allows rapid and almost quantitative construction of modified nucleotides derived from thio- and selenophosphorus acids.
Titel: |
New phosphitylating reagent in the nucleotide chemistry containing two 4-nitrophenoxy leaving groups. Remarkably fast and clean phosphitylations activated by DBU leading to thio- and seleno-oligonucleotides
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Autor/in / Beteiligte Person: | Heliński, Jan ; Da¸bkowski, Wojciech ; Michalski, Jan |
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Zeitschrift: | Tetrahedron Letters, Jg. 34 (1993-10-01), S. 6451-6454 |
Veröffentlichung: | Elsevier BV, 1993 |
Medientyp: | unknown |
ISSN: | 0040-4039 (print) |
DOI: | 10.1016/0040-4039(93)85068-8 |
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