Identification of Novel Mutations in LprG ( rv1411c ), rv0521 , rv3630 , rv0010c , ppsC , and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis
In: Antimicrobial Agents and Chemotherapy, Jg. 62 (2018-07-01)
Online
unknown
Zugriff:
Despite progress, the mechanisms of action and resistance of pyrazinamide (PZA) are not well understood. We characterized 109 mutants resistant to pyrazinoic acid (POA), the active form of PZA, and found that while most ( n = 101 [93%]) mutants had panD mutations and 4 (4%) had clpC1 mutations (S91G), new mutations in lprG ( rv1411c ) and rv0521 ( n = 4 [4%]), rv3630 , rv0010c , ppsC , and cyp128 (cytochrome P450 128) were identified, shedding new light on the mechanisms of action and resistance of PZA in M. tuberculosis .
| Titel: |
Identification of Novel Mutations in LprG ( rv1411c ), rv0521 , rv3630 , rv0010c , ppsC , and cyp128 Associated with Pyrazinoic Acid/Pyrazinamide Resistance in Mycobacterium tuberculosis
|
|---|---|
| Autor/in / Beteiligte Person: | Shi, Wanliang ; Chen, Jiazhen ; Zhang, Wenhong ; Zhang, Ying ; Zhang, Shuo |
| Link: | |
| Zeitschrift: | Antimicrobial Agents and Chemotherapy, Jg. 62 (2018-07-01) |
| Veröffentlichung: | American Society for Microbiology, 2018 |
| Medientyp: | unknown |
| ISSN: | 1098-6596 (print) ; 0066-4804 (print) |
| DOI: | 10.1128/aac.00430-18 |
| Schlagwort: |
|
| Sonstiges: |
|