Piperhancins A and B, Two Pairs of Antineuroinflammatory Cycloneolignane Enantiomers from Piper hancei
In: The Journal of Organic Chemistry, Jg. 86 (2021-03-23), S. 5284-5291
Online
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Zugriff:
Two pairs of cycloneolignane enantiomers, piperhancins A and B (1 and 2, respectively), along with two enantiomeric pairs of biosynthetic related neolignanes, hancinone C (3) and piperhancin C (4), were isolated from the stems of Piper hancei. Compound 1 is an unprecedented 1',2:1,2'-dicyclo-8,3'-neolignane. Their structures and absolute configurations were elucidated by spectroscopic analyses, X-ray diffraction, and electronic circular dichroism calculations. Among all of the isolates, compounds (+)-1, (-)-1, (+)-2, (-)-2, and (+)-3 could significantly inhibit the production of nitric oxide secreted by lipopolysaccharide (LPS)-induced neuroinflammation in BV-2 microglial cells, with IC50 values of 1.1-26.3 μM. In addition, compound (-)-1 could decrease the mRNA levels of iNOS, IL-6, and TNF-α induced by LPS in BV-2 microglial cells.
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Piperhancins A and B, Two Pairs of Antineuroinflammatory Cycloneolignane Enantiomers from Piper hancei
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Autor/in / Beteiligte Person: | Li, Hua ; Liao, Hai-Bing ; Su, Bao-Jun ; Hu, Ya-Jie ; Liu, Jin-Long ; Wang, Ya-Qi ; Liang, Dong ; Yang, Fan |
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Zeitschrift: | The Journal of Organic Chemistry, Jg. 86 (2021-03-23), S. 5284-5291 |
Veröffentlichung: | American Chemical Society (ACS), 2021 |
Medientyp: | unknown |
ISSN: | 1520-6904 (print) ; 0022-3263 (print) |
DOI: | 10.1021/acs.joc.1c00240 |
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