DBU mediated confluent approach for the one pot synthesis of novel 5-hydroxy pyrazolo[1,2- a ][1,2,4]triazoles and their dehydration to novel pyrazolo[1,2- a ][1,2,4]triazole derivatives
In: Tetrahedron, Jg. 72 (2016-07-01), S. 3986-3993
Online
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Zugriff:
A series of novel alkyl 5-hydroxy-7-aryl-5-methyl-1,3-dioxo-2-phenyl hexahydropyrazolo[1,2-a][1,2,4]triazole-6-carboxylates and alkyl 5-aryl-7-methyl-1,3-dioxo-2-phenyl-1,2,3,5-tetra hydropyrazolo[1,2-a][1,2,4]triazole-6-carboxylates have been synthesized. The synthesis of hydroxy pyrazolo[1,2-a][1,2,4]triazoles has been achieved by DBU mediated one pot reaction of aromatic aldehydes, alkyl acetoacetates and 4-phenylurazole at 35 °C in ethanol–water (1:1). Dehydration of hydroxy pyrazolo[1,2-a][1,2,4]triazoles has been achieved using conc. H2SO4 to afford dehydrated pyrazolo[1,2-a][1,2,4]triazoles in high yields. The structural assignments have been made by spectral data and unambiguously confirmed by X-ray analysis. Good yields, operational simplicity and moderate conditions are the advantages of the reactions.
Titel: |
DBU mediated confluent approach for the one pot synthesis of novel 5-hydroxy pyrazolo[1,2- a ][1,2,4]triazoles and their dehydration to novel pyrazolo[1,2- a ][1,2,4]triazole derivatives
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Autor/in / Beteiligte Person: | Gupta, Shruti ; Khurana, Jitender M. ; Saluja, Pooja |
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Zeitschrift: | Tetrahedron, Jg. 72 (2016-07-01), S. 3986-3993 |
Veröffentlichung: | Elsevier BV, 2016 |
Medientyp: | unknown |
ISSN: | 0040-4020 (print) |
DOI: | 10.1016/j.tet.2016.05.021 |
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