Analgesic, Anti-Inflammatory and CNS Depressant Activities of Methanolic Extract of Sonneratia alba Leaves in Mice
In: Natural Products Chemistry & Research, 2017
Online
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Zugriff:
Objectives: The present examine was going to evaluate the pain killer, anti-inflammatory, and CNS depressant activities of the methanolic extract of the Sonneratia clear leaves (MESAL). Materials and methods: By using carrageenan-induced inflamed method anti-inflammatory effects regarding MESAL were studied right here at the dose of 150 mg/kg and 300 mg/kg body mass. Analgesic activity of MESAL was evaluated by applying formalin-induced licking and gnawing at activities in mice at a dose of 200 mg/kg and 400 mg/kg body weight. The CNS depressant activity has been measured by observing typically the reduction of locomotors in addition to exploratory activities on view discipline and hole cross assessments at a dose regarding 200 and 400 mg/kg bodyweight. Results: Statistical analysis revealed that dose of 400 mg/kg displayed pct of protection (86.29%) of licking in addition to biting of formalin-induced rodents at late phase compared to diclofenac sodium (78.23%). The dose of one hundred fifty mg/kg showed sustained inhibited (17.27% and twenty-two 94%) of paw edema at the 2nd and 3rd hour compared with standard diclofenac sodium (15.93% and 17.47%). Additionally, doses of 3 hundred mg/kg caused the higher percent of sustained inhibition regarding paw edema at every single hour compared with common diclofenac sodium. Besides, the flower extract also had considerable (p
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Analgesic, Anti-Inflammatory and CNS Depressant Activities of Methanolic Extract of Sonneratia alba Leaves in Mice
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Autor/in / Beteiligte Person: | Nesa, L ; Asad, S ; Mdh, Kawsar ; Mdd, Sohel ; Kn, Deepa |
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Zeitschrift: | Natural Products Chemistry & Research, 2017 |
Veröffentlichung: | OMICS Publishing Group, 2017 |
Medientyp: | unknown |
ISSN: | 2329-6836 (print) |
DOI: | 10.4172/2329-6836.1000277 |
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