Comprehensive genomic profiling (CGP) of chromophobe renal cell carcinoma (chrRCC) compared with clear cell RCC (ccRCC): Impact of FLCN genomic alteration (GA) status
In: Journal of Clinical Oncology, Jg. 40 (2022-02-20), S. 292-292
Online
unknown
Zugriff:
292 Background: FLCN is a tumor suppressor gene associated with cutaneous hair follicle development. FLCN germline mutations are linked to inherited chrRCC in the Birt-Hogg-Dube (BHD) syndrome. We queried whether clinically sporadic chrRCC featured FLCN mutations by comparing the genomic profiles of chrRCC with ccRCC. Methods: 108 chrRCC and 2110 ccRCC underwent hybrid-capture based comprehensive genomic profiling (CGP) to evaluate all classes of genomic alterations (GA). Tumor mutational burden (TMB) was determined on up to 1.1 Mbp of sequenced DNA and microsatellite instability (MSI) was determined on 114 loci. PD-L1 expression was determined by IHC (Dako 22C3). Results: Patients (pts) with chrRCC were more frequently female and younger than pts with ccRCC p
Titel: |
Comprehensive genomic profiling (CGP) of chromophobe renal cell carcinoma (chrRCC) compared with clear cell RCC (ccRCC): Impact of FLCN genomic alteration (GA) status
|
---|---|
Autor/in / Beteiligte Person: | Bratslavsky, Gennady ; Necchi, Andrea ; Spiess, Philippe E. ; Grivas, Petros ; Joseph M Jacob ; Kravtsov, Oleksandr ; Richard S.P. Huang ; Parini, Vamsi ; Decker, Brennan ; Lin, Douglas I. ; Pavlick, Dean C. ; Danziger, Natalie ; Ross, Jeffrey S. |
Link: | |
Zeitschrift: | Journal of Clinical Oncology, Jg. 40 (2022-02-20), S. 292-292 |
Veröffentlichung: | American Society of Clinical Oncology (ASCO), 2022 |
Medientyp: | unknown |
ISSN: | 1527-7755 (print) ; 0732-183X (print) |
DOI: | 10.1200/jco.2022.40.6_suppl.292 |
Schlagwort: |
|
Sonstiges: |
|