ChemInform Abstract: Direct α-Amination of Nitrones Achieved by DBU-Activated N-Haloimides
In: ChemInform, Jg. 47 (2016-11-01)
Online
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Zugriff:
Direct α-amination of nitrones has been developed by using N-haloimide-DBU protocol. Reaction of nitrones with N-haloimide takes place readily in the presence of DBU in DCM, affording directly α-aminonitrones in moderate to excellent yields. N-Haloimide activated by DBU provides both a halogen cation and a nitrogen anion source. E- and Z-isomerization of α-aminonitrones was examined and found to be highly sensitive to acidic substances like silica gel and Bronsted acid. In addition to nitrones, quinoline N-oxides are also suitable substrates. Direct amination achieved by the protocol demonstrates new reactivity of nitrones and quinoline N-oxides.
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ChemInform Abstract: Direct α-Amination of Nitrones Achieved by DBU-Activated N-Haloimides
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Autor/in / Beteiligte Person: | Liang, Fushun ; Li, Mengru |
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Zeitschrift: | ChemInform, Jg. 47 (2016-11-01) |
Veröffentlichung: | Wiley, 2016 |
Medientyp: | unknown |
ISSN: | 0931-7597 (print) |
DOI: | 10.1002/chin.201649044 |
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