Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies
In: Journal of Perinatal Medicine, Jg. 47 (2019-02-28), S. 534-538
Online
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Zugriff:
Objective To demonstrate clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies. Methods We retrospectively evaluated 75-g GTT screening results of 356 pregnancies without prompt diagnosis of gestational diabetes mellitus (GDM) between January 2013 and December 2017. Newborns with a birthweight greater than the 90th percentile were evaluated as LGA. Pregnancies with LGA and non-LGA fetuses were compared by demographic and historical factors – maternal age, gravidity, parity, birthweight, birthweek, GTT results and birthweight percentiles – via Student’s t-test. Multiple linear regression using the backward elimination method was performed to define the correlation between parameters and LGA (P-value of Results The cohort was consisted of 45 (12.6%) and 311 (87.4%) pregnancies with LGA and non-LGA fetuses, respectively. Maternal age and 2nd-h GTT results were found to be significantly higher in patients with LGA newborns (Pst-h results were also higher (P=0.112, P=0.065). The coefficient of multiple determination (R2) was 0.055 by multiple linear regression analysis. Accordingly, GTT 2nd-h result and maternal age were statistically significant and contributed to the explanation of LGA, although the R2 value was not that much higher (P=0.016; P=0.001). Maternal age and GTT 2nd-h results were found to be associated with LGA fetuses with area under the curve (AUC) values of 0.662 and 0.608 according to ROC curve analysis. Conclusion Maternal age and 75-g GTT 2nd-h results were significantly higher in gestations with LGA newborns without GDM.
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Clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies
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Autor/in / Beteiligte Person: | Tanacan, Atakan ; Mehmet Sinan Beksac ; Unal, Canan ; Duygu Aydin Hakli ; Fadiloglu, Erdem |
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Zeitschrift: | Journal of Perinatal Medicine, Jg. 47 (2019-02-28), S. 534-538 |
Veröffentlichung: | Walter de Gruyter GmbH, 2019 |
Medientyp: | unknown |
ISSN: | 1619-3997 (print) ; 0300-5577 (print) ; 2018-0373 (print) |
DOI: | 10.1515/jpm-2018-0373 |
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