A four-antibody immunohistochemical panel can distinguish clinico-pathological clusters of urothelial carcinoma and reveals high concordance between primary tumor and lymph node metastases
In: Virchows Archiv, Jg. 478 (2020-10-30), S. 637-645
Online
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Zugriff:
Urothelial carcinoma of the bladder (UC) has a poor prognosis, partly because of chemotherapy resistance. Molecular classifications have shown their interest and can help to offer personalized treatment. In this study, we evaluated the feasibility of an immunohistochemical study to divide advanced UC into clinico-pathological-molecular subgroups and evaluate phenotypic correspondence between primary UC and matched lymph node metastases (LMN). An eight-antibody immunohistochemical panel was performed on UC and matched LMN from patients treated with radical cystectomy. One hundred eighty-seven UCs (100 pN0 tumor and 87 pN+ tumor) were tested. Multiple correspondence analysis showed that UC expressing GATA3 also expressed FOXA1 (p = 0.010) and did not stain for CK5/6 (p = 0.031) nor CK14 (p = 0.003). UC expressing CK14 coexpressed CK5/6 (p
| Titel: |
A four-antibody immunohistochemical panel can distinguish clinico-pathological clusters of urothelial carcinoma and reveals high concordance between primary tumor and lymph node metastases
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| Autor/in / Beteiligte Person: | Rialland, Thomas ; Compérat, Eva ; Cussenot, Olivier ; Bontoux, Christophe |
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| Zeitschrift: | Virchows Archiv, Jg. 478 (2020-10-30), S. 637-645 |
| Veröffentlichung: | Springer Science and Business Media LLC, 2020 |
| Medientyp: | unknown |
| ISSN: | 1432-2307 (print) ; 0945-6317 (print) |
| DOI: | 10.1007/s00428-020-02951-0 |
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