DBU-Promoted Formal [4+2] Annulation Reactions of o-Chloromethyl Anilines with Azlactones
In: Synthesis, Jg. 53 (2020-11-02), S. 1349-1355
Online
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Zugriff:
An efficient 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-mediated formal [4+2] annulation reaction of aza-ortho-quinone methides (aza-oQMs) (generated from o-chloromethyl anilines) with enolates (formed from azlactones) is disclosed, delivering biologically significant 3,4-dihydroquinolin-2(1H)-one derivatives in moderate to good yields. The salient features of this reaction include readily accessible starting materials, broad substrate scope, mild reaction conditions, removable protecting groups, and a scalable synthetic approach.
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DBU-Promoted Formal [4+2] Annulation Reactions of o-Chloromethyl Anilines with Azlactones
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Autor/in / Beteiligte Person: | Xu, Jianfeng ; Ji, Haojie ; Fu, Weijun ; Gao, Hongjie ; He, Chonglong |
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Zeitschrift: | Synthesis, Jg. 53 (2020-11-02), S. 1349-1355 |
Veröffentlichung: | Georg Thieme Verlag KG, 2020 |
Medientyp: | unknown |
ISSN: | 1437-210X (print) ; 0039-7881 (print) |
DOI: | 10.1055/s-0040-1706549 |
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