Caffeine impairs intramuscular energy balance in patients susceptible to malignant hyperthermia
In: Muscle & Nerve, Jg. 28 (2003-07-23), S. 353-358
Online
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Zugriff:
Malignant hyperthermia (MH) is a metabolic myopathy with an abnormal release of calcium by the sarcoplasmic reticulum (SR), triggered by volatile anesthetics and succinylcholine. Similarly, caffeine enhances Ca(2+)release by the SR in vitro. In a prospective, randomized study, high-energy phosphates were studied by intramuscular 31-phosphorus magnetic resonance spectroscopy ((31)P-MRS) in 10 MH-susceptible (MHS) and 7 MH-nonsusceptible (MHN) subjects before and after injection of 0.5 ml caffeine (20 mM). Intramuscular energy balance, measured by the ratios of P(i)/PCr and P(i)/gamma-ATP, did not differ between MHS and MHN patients before and after intramuscular caffeine injection. However, within each group, P(i)/PCr and P(i)/gamma-ATP increased significantly only in the MHS group. Intramuscular caffeine injection seemed to impair the metabolic balance in MHS individuals. This may reflect a local calcium overload leading to consumption of high-energy phosphates and increase of inorganic phosphate. Intramuscular stimulation by caffeine and (31)P-MRS may provide a valuable tool to investigate MH-related metabolic disturbances.
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Caffeine impairs intramuscular energy balance in patients susceptible to malignant hyperthermia
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Autor/in / Beteiligte Person: | Beer, Meinrad ; Köstler, Herbert ; Kenn, Werner ; Anetseder, Martin ; Hahn, Dietbert ; Kagerbauer, Erwin ; Textor, Zoran ; Roewer, Norbert |
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Zeitschrift: | Muscle & Nerve, Jg. 28 (2003-07-23), S. 353-358 |
Veröffentlichung: | Wiley, 2003 |
Medientyp: | unknown |
ISSN: | 0148-639X (print) |
DOI: | 10.1002/mus.10445 |
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