Polynuclear complexes of a new macrocyclic oxamide metalloligand: Syntheses, crystal structures and deoxyribonucleic acid cleavage and magnetic properties
In: Inorganica Chimica Acta, Jg. 395 (2013), S. 197-202
Online
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Zugriff:
A mononuclear macrocyclic oxamide complex CuL was used as a new metalloligand to prepare polynuclear complexes, by which a new tetranuclear complex {Mn[CuL(ClO4)]3}·H3O·2.5H2O (1) and a new trinuclear complex {Cu[CuL(CH3OH)]2(ClO4)2} (2) were obtained (H2 L = dimethyl 5,6,7,8,15,16-hexahydro-6,7-dioxodibenzo-[1,4,8,11]tetraazacyclotetradecine-13,18-dicarboxylate). X-ray single crystal analysis revealed that every Cu(II) centre of the CuL metalloligand is coordinated by the four N atoms from the macrocyclic oxamide ligand and an O atom from a ClO4− anion in 1 or a CH3OH molecule in 2, with the four N atoms forming the square base and the O atom occupying the vertex of the distorted square pyramidal coordination geometry. Plasmid DNA cleavage experiments showed that complexes CuL, 1 and 2 all have cleavage activities in the absence of any added oxidizing agents and that 2 has the highest cleavage efficiency among the three complexes in Tris–HCl buffer. Synergistic effects between the Cu(II) centers may contribute to the higher DNA cleavage efficiency of 2 in Tris–HCl buffer. Magnetism studies over the temperature range 2–300 K showed pronounced antiferromagnetic interactions between the oxamido-bridged metal centers in both 1 and 2.
Titel: |
Polynuclear complexes of a new macrocyclic oxamide metalloligand: Syntheses, crystal structures and deoxyribonucleic acid cleavage and magnetic properties
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Autor/in / Beteiligte Person: | Li, Chang-Xin ; Ren, Shi ; Li, Xiao-Zeng ; Zhu, Li-Na ; Shi, Xiao-Ming |
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Zeitschrift: | Inorganica Chimica Acta, Jg. 395 (2013), S. 197-202 |
Veröffentlichung: | Elsevier BV, 2013 |
Medientyp: | unknown |
ISSN: | 0020-1693 (print) |
DOI: | 10.1016/j.ica.2012.11.003 |
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