Effects of SARS-CoV-2 P.1 introduction and the impact of COVID-19 vaccination on the epidemiological landscape of São José Do Rio Preto, Brazil
Cold Spring Harbor Laboratory, 2021
Online
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Zugriff:
The emergence of the new Brazilian variant of concern, P.1 lineage (Gamma), raised concern about its impact on the epidemiological profile of COVID-19 cases due to its higher transmissibility rate and immune evasion ability. Using 272 whole-genome sequences combined with epidemiological data, we showed that P.1 introduction in São José do Rio Preto, São Paulo, Brazil, was followed by the displacement of eight circulating SARS-CoV-2 variants and a rapid increase in prevalence two months after its first detection. Our findings support that the P.1 variant is associated with an increase in mortality risk and severity of COVID-19 cases in younger aged groups, which corresponds to the unvaccinated population at the time. Moreover, our data highlight the beneficial effects of vaccination indicated by a pronounced reduction of severe cases and deaths in immunized individuals, reinforcing the need for rapid and massive vaccination.
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Effects of SARS-CoV-2 P.1 introduction and the impact of COVID-19 vaccination on the epidemiological landscape of São José Do Rio Preto, Brazil
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Autor/in / Beteiligte Person: | Rafael Alves da Silva ; Maisa Carla Pereira Parra ; Fernanda Simoes Dourado ; Althouse, Benjamin M. ; Gislaine Celestino Dutra da Silva ; Victor Miranda Hernandes ; Zini, Nathalia ; Versiani, Alice F. ; Leila Sabrina Ullmann ; Rahal, Paula ; Bittar, Cíntia ; Edoardo Estevam de Oliveira Lobl ; Cecilia Artico Banho ; Fábio Sossai Possebon ; Michela Dias Barcelos ; Leonardo Cecílio da Rocha ; Campos, Guilherme ; Cohen, Jamie A. ; Vasilakis, Nikos ; Patuto, Caio ; Bruno Henrique Gonçalves de Aguiar Milhim ; Sacchetto, Lívia ; Ana Carolina Boldrin ; Beatriz de Carvalho Marques ; Maurício Lacerda Nogueira ; Marilia Mazzi Moraes ; Victoria Bernardi Ciconi ; João Pessoa Araújo ; Cássia Fernanda Estofolete ; Andresa Lopes dos Santos ; Helena Lage Ferreira ; Andreia Francesli Negri ; Carolina Colombelli Pacca ; Thayza dos Santos |
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Veröffentlichung: | Cold Spring Harbor Laboratory, 2021 |
Medientyp: | unknown |
DOI: | 10.1101/2021.07.28.21261228 |
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