45 FOLLOW UP EVALUATION OF NEONATES TREATED WITH DRUGS AND HYPERVENTILATION FOR SEVERE PERSISTENT PULMONARY HYPERTENSION (PPHN)

12 infants were treated for PPHN from 1978 to 1980; nine survived. We were able to evaluate 5 of 7 [xBW=2.1 kg, xGA=37 (32-40), x5m Apgar=7] infants now >6 months old, who are being followed by their referring pediatricians. Surviving infants suffered episodes of hypo and hyperoxia 5/5, hypotension 3/5, and hypo and hypercarbia 5/5. An electrocardiogram, vector-cardiogram, and echocardiogram, chest x-ray, arterial blood gas, ophthalmologic exam, computerized brain scan (CAT), Bayley Scale of Infant Development, and physical examination by a pediatric cardiologist were done on each patient. No child was completely normal. Abnormalities include evidence of residual or previously undiagnosed cardiopulmonary disease in 3/5, minor CAT scan abnormalities in 3/5, and severe abnormality in 1/5, developmental delay in two children, severe in one (DQ