Fischdiabietane A, an Antitumoral Diterpenoid Dimer Featuring an Unprecedented Carbon Skeleton from Euphorbia fischeriana
In: The Journal of Organic Chemistry, Jg. 86 (2021-04-01), S. 5894-5900
Online
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Zugriff:
Fischdiabietane A (1), a novel asymmetric diterpenoid dimer with a unique nonacyclic 6/6/6/5/7/6/6/6/6 ring system possessing unprecedented 2-oxaspiro[4.5]decane-1-one and 2-oxabicyclo[3.2.2]nonane frameworks in D/E/F rings, was isolated from the roots of Euphorbia fischeriana. Its structure was determined by spectroscopic techniques, electronic circular dichroism calculations, and X-ray diffraction experiments. Notably, 1 is the first abietane-type [4 + 2] Diels-Alder dimer identified from nature. The IC50 of 1 against T47D cells was about sixfold higher than that of cisplatin (the positive control). Furthermore, 1 induced apoptosis in T47D cells through the activation of caspase-3 and the degradation of poly(ADP-ribose) polymerase.
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Fischdiabietane A, an Antitumoral Diterpenoid Dimer Featuring an Unprecedented Carbon Skeleton from Euphorbia fischeriana
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Autor/in / Beteiligte Person: | Xu, Jie-Kun ; He, Jun ; Lian, Wen-Wen ; Guo, Lin-Bo ; Tian, Hai-Yan ; Xia, Cong-Yuan ; Zhang, Wei-Ku ; Shi, Ying-Xue ; Zhang, Jia |
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Zeitschrift: | The Journal of Organic Chemistry, Jg. 86 (2021-04-01), S. 5894-5900 |
Veröffentlichung: | American Chemical Society (ACS), 2021 |
Medientyp: | unknown |
ISSN: | 1520-6904 (print) ; 0022-3263 (print) |
DOI: | 10.1021/acs.joc.1c00305 |
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