Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency
In: Nano Research, Jg. 11 (2018-03-19), S. 2285-2294
Online
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Zugriff:
Based on the unique advantages of fluorescent silicon nanoparticles (SiNPs), long circulation red blood cells (RBCs), and anti-cancer drug molecules (i.e., doxorubicin (DOX)), we developed multifunctional DOX-loaded SiNPs impregnated into RBCs. Importantly, the resulting drug delivery systems (DDSs) simultaneously exhibited bright fluorescence coupled with robust photostability (i.e., ∼ 24% loss of fluorescent intensity after 25 min continuous laser irradiation) and significantly lengthened blood residency (i.e., t1/2 = 7.31 ± 0.96 h, 3.9-fold longer than pure DOX-loaded SiNPs). Therefore, this novel DDS featuring multi-functionalities shows high potential for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in a synchronous manner.
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Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency
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Autor/in / Beteiligte Person: | Jiang, Airui ; He, Yao ; Peng, Fei ; Ji, Xiaoyuan ; Song, Bin ; Wang, Houyu ; Su, Yuanyuan |
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Zeitschrift: | Nano Research, Jg. 11 (2018-03-19), S. 2285-2294 |
Veröffentlichung: | Springer Science and Business Media LLC, 2018 |
Medientyp: | unknown |
ISSN: | 1998-0000 (print) ; 1998-0124 (print) |
DOI: | 10.1007/s12274-017-1850-6 |
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