Labile Plasma Iron (LPI), More Practical and More Sensitive to Iron Overload in Myelodysplastic Syndromes

Background: In order to gain an insight into LPI in iron metabolism microenvironment in MDS. Materials and Methods: We performed ELISA, quantitative RT-PCR, flow cytometry, MRI T2* assays to test LPI, iron biochemical parameters and LIC among 22 MDS patients. Results: LPI has a statistical difference (P Conclusion: LPI seems to be a real-time indicator which reflects body iron loading status instantaneously. Despite the limited knowledge available on LPI speciation in different types and degrees of IO, LPI measurements can be and are in fact used for identifying systemic IO and for initiating/adjusting chelation regimens. Before DFO treatment, a patient had an abnormal liver function. Along with iron chelation therapy, his LPI decreased rapidly. Meanwhile, his ALT dropped and his hemoglobin increased gradually. Furthmore, his LIC decreased after receiving DFO treatment. Lane a: LIC was 9.97mg/g dry weight on week 0. Lane b: LIC was 5.81mg/g dry weight on week 26. Figure 1. The improvement of ALT, hemoglobin and LIC Figure 1. The improvement of ALT, hemoglobin and LIC Figure 2. Figure 2. Disclosures No relevant conflicts of interest to declare.