Effect of low level laser treatment after installation of dental titanium implant-immunohistochemical study of vascular endothelial growth factor: an experimental study in rats

This experiment using an animal experimental model was conducted in order to investigate the effect of low-level laser therapy (LLLT) on the healing of the dental titanium implant. The experimental group received LLLT for a week and the control group did not. Each group consisted of 10 rats. Two rats from the groups were euthenized on the day 1, 3, 7, 14, and 21 of the experiment. The expression of vascular endothelial growth factor (VEGF) was investigated. The expression of VEGF was observed from the initial stage of the installation of the implant for both the experimental and control groups. However, the degree of expression was higher in the experimental group. Bone density after installation of dental titanium implant during osseointegration in the experimental group was higher than the control group. The surface and structure of the titanium implant was not damaged by LLL. From the above results, the expression of VEGF during the osseointegration of the dental titanium implant was observed within bone tissue. The application of the low-level laser influenced the expression of VEGF, and resulted in the expansion of metabolic angiogenesis and increased the activity of bone tissue cells.