DICUMAROL-2-C14: SYNTHESIS AND METABOLISM STUDIES
In: Canadian Journal of Chemistry, Jg. 30 (1952-04-01), S. 245-250
Online
unknown
Zugriff:
Dicumarol (3,3′-methylene bis(4-hydroxycoumarin)) has been synthesized labeled with C14 in the 2-position. Starting with active barium carbonate of specific activity 1.6 µc.per mgm., the intermediate compounds diethyl carbonate-1-C14 and 4-hydroxycoumarin-2-C14 were prepared. Subsequent reaction of the latter compound with aqueous formaldehyde yielded dicumarol-2-C14. The specific activity of the final product, once recrystallized from cyclohexanone, was 4.3 × 105 counts per min. per mgm. corrected for geometry and absorption. The expired carbon dioxide from a mouse injected with this C14-labeled product was collected and found to contain no radioactivity. This indicated that, in this animal, the 2-carbon of dicumarol does not enter into a metabolic process whereby it is expired as carbon dioxide.
Titel: |
DICUMAROL-2-C14: SYNTHESIS AND METABOLISM STUDIES
|
---|---|
Autor/in / Beteiligte Person: | Jaques, L. B. ; Eisenhauer, H. R. ; Pepper, J. M. ; Spinks, J. W. T. |
Link: | |
Zeitschrift: | Canadian Journal of Chemistry, Jg. 30 (1952-04-01), S. 245-250 |
Veröffentlichung: | Canadian Science Publishing, 1952 |
Medientyp: | unknown |
ISSN: | 1480-3291 (print) ; 0008-4042 (print) |
DOI: | 10.1139/v52-035 |
Schlagwort: |
|
Sonstiges: |
|