Danshen protects kidney grafts from ischemia/reperfusion injury after experimental transplantation
In: Transplant International, Jg. 22 (2008-10-13), S. 232-241
Online
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Zugriff:
Summary Danshen (DS) is used for treatment of various ischemic events in the traditional Chinese medicine. Hence, this study was designed to investigate its effect on ischemia/reperfusion injury (IRI) after experimental kidney transplantation (eKTx). Nephrectomized Sprague–Dawley rats underwent eKTx. Some animals were infused with 1.5 ml DS 10 min before surgery. Kidney grafts were transplanted after cold storage for 20 h in Histidine–Tryptophane–Ketoglutarate solution. After reperfusion blood samples were collected for blood urinary nitrogen (BUN), creatinine, lactate dehydrogenase (LDH), and alanine transaminase. Further, tissue was assessed for morphologic and pathophysiologic changes. Donor preconditioning with DS (DS-d) significantly decreased BUN, creatinine, LDH, and aspartate aminotransferase to 65–97% of controls while preconditioning of the recipient (DS-r) decreased values to 58–82% (P
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Danshen protects kidney grafts from ischemia/reperfusion injury after experimental transplantation
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Autor/in / Beteiligte Person: | Ludwig, Jochen ; Nickkholgh, Arash ; Kern, Michael A. ; Schemmer, Peter ; Büchler, Markus W. ; Chen, Jing ; Bruns, Helge ; Guan, Xiaohai ; Liang, Rui ; Dei-Anane, Genevieve ; Gross, Marie-Luise |
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Zeitschrift: | Transplant International, Jg. 22 (2008-10-13), S. 232-241 |
Veröffentlichung: | Frontiers Media SA, 2008 |
Medientyp: | unknown |
ISSN: | 0934-0874 (print) |
DOI: | 10.1111/j.1432-2277.2008.00770.x |
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