Meta-analysis of bioabsorbable versus durable polymer drug-eluting stents in 20,005 patients with coronary artery disease: An update
In: Catheterization and Cardiovascular Interventions, Jg. 83 (2014-02-10), S. E193- (14S.)
Online
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Zugriff:
Objectives To perform an updated meta-analysis comparing biodegradable polymer drug eluting stents (BP-DES) and durable polymer drug eluting stents (DP-DES). Background BP-DES have been suggested to reduce late stent thrombosis (LST) rates as compared to first generation DP-DES. Recently, second generation DP-DES have replaced older DES, but comparison of these stents with BP-DES has not yielded consistent results. Methods Medline/Web databases were searched for studies comparing BP-DES and DP-DES, and reporting rates of overall/cardiac mortality, myocardial infarction (MI), LST, target lesion revascularization (TLR) and target vessel revascularization (TVR) and late lumen loss (LLL), with a follow-up ≥6 months. Results Twenty studies (20,005 patients) were included in the meta-analysis. Median follow-up time was 1 year. Compared with DP-DES, BP-DES showed lower LLL (in stent: weighted mean difference WMD −0.45 mm, 95% CI −0.66 to −0.24 mm, P = 0.00001; in segment: WMD −0.15 mm, 95% CI = −0.24 to −0.06 mm, P = 0.001) and lower rates of LST (OR 0.51, 95% CI = 0.30 to 0.86, P = 0.01), although they did not improve mortality, MI, TLR, and TVR rates. BP-DES coated with sirolimus or novolimus, in comparison with biolimus or paclitaxel, were associated with reduced LLL (P
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Meta-analysis of bioabsorbable versus durable polymer drug-eluting stents in 20,005 patients with coronary artery disease: An update
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Autor/in / Beteiligte Person: | Sheiban, Imad ; Agostoni, Pierfrancesco ; Lazzero, Maurizio ; Gioel Gabrio Secco ; Lupi, Alessandro ; Bongo, Angelo S. ; Rognoni, Andrea ; Porto, Italo ; Bolognese, Leonardo ; Fattori, Rossella |
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Zeitschrift: | Catheterization and Cardiovascular Interventions, Jg. 83 (2014-02-10), S. E193- (14S.) |
Veröffentlichung: | Wiley, 2014 |
Medientyp: | unknown |
ISSN: | 1522-1946 (print) |
DOI: | 10.1002/ccd.25416 |
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