Regio- and diastereoselective synthesis of 3,4-dihydro-2H-benzo [4,5]imidazo[2,1-b] [1,3]thiazine derivatives via DBU-catalyzed [3+3] annulation of MBH carbonates with 2-mercaptobenzimidazoles
In: Tetrahedron, Jg. 98 (2021-10-01), S. 132430-132430
Online
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Zugriff:
Benzimidazo [2,1-b] [1,3]thiazines as an important class of N,S-containing heterocyclic compounds are usually present in molecules with diverse biological and pharmaceutical activities. An efficient DBU-catalyzed [3 + 3] annulation reaction between Morita-Baylis-Hillman carbonates and 2-mercaptobenzimidazoles has been developed. Under mild reaction conditions, a wide range of functionalized 3,4-dihydro-2H-benzo[4,5]imidazo [2,1-b][1,3]thiazines possessing two contiguous stereogenic centers on thiazine ring were prepared in moderate to excellent yields (48–93%) and diastereoselectivities (59:41 to >95:5).
Titel: |
Regio- and diastereoselective synthesis of 3,4-dihydro-2H-benzo [4,5]imidazo[2,1-b] [1,3]thiazine derivatives via DBU-catalyzed [3+3] annulation of MBH carbonates with 2-mercaptobenzimidazoles
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Autor/in / Beteiligte Person: | Yu, Liu-Dong ; Peng, Pei-Ying ; Yuan, Minglong ; Dengbang, Jiang ; Wang, Yi-Dan ; Li, Hongli ; Jiang, Lin ; Yuan, Mingwei |
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Zeitschrift: | Tetrahedron, Jg. 98 (2021-10-01), S. 132430-132430 |
Veröffentlichung: | Elsevier BV, 2021 |
Medientyp: | unknown |
ISSN: | 0040-4020 (print) |
DOI: | 10.1016/j.tet.2021.132430 |
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