Elevated plasma p-tau181 levels unrelated to Alzheimer’s disease pathology in amyotrophic lateral sclerosis
In: Journal of Neurology, Neurosurgery & Psychiatry, Jg. 94 (2023-04-03), S. 428-435
Online
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Zugriff:
BackgroundPhosphorylated-tau181 (p-tau181), a specific marker of Alzheimer’s disease (AD) pathology, was found elevated in plasma but not in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). We expanded these findings in a larger patient cohort, exploring clinical/electrophysiological associations, prognostic value and longitudinal trajectories of the biomarker.MethodsWe obtained baseline plasma samples from 148 ALS, 12 spinal muscular atrophy (SMA), and 88 AD patients, and 60 healthy controls. Baseline CSF and longitudinal plasma samples were from 130 and 39 patients with ALS. CSF AD markers were measured with the Lumipulse platform, and plasma p-tau181 with SiMoA.ResultsPatients with ALS showed higher plasma p-tau181 levels than controls (pConclusionsPlasma p-tau181 is elevated in patients with ALS, independently from CSF levels, and is firmly associated with LMN dysfunction. The finding indicates that p-tau181 of putative peripheral origin might represent a confounding factor in using plasma p-tau181 for AD pathology screening, which deserves further investigation.
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Elevated plasma p-tau181 levels unrelated to Alzheimer’s disease pathology in amyotrophic lateral sclerosis
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Autor/in / Beteiligte Person: | Vacchiano, Veria ; Mastrangelo, Andrea ; Zenesini, Corrado ; Baiardi, Simone ; Avoni, Patrizia ; Polischi, Barbara ; Capellari, Sabina ; Salvi, Fabrizio ; Liguori, Rocco ; Parchi, Piero |
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Zeitschrift: | Journal of Neurology, Neurosurgery & Psychiatry, Jg. 94 (2023-04-03), S. 428-435 |
Veröffentlichung: | BMJ, 2023 |
Medientyp: | unknown |
ISSN: | 1468-330X (print) ; 0022-3050 (print) |
DOI: | 10.1136/jnnp-2022-330709 |
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